Last Updated: October 2025
Is your Synjardy or Synjardy XR prescription costing you too much? If so, you’re not alone. Empagliflozin metformin, also known as Synjardy or Synjardy XR, is a prescription medication used to treat type 2 diabetes. Unfortunately, paying the full cost of this drug each month can be challenging without an insurance plan, a Synjardy coupon, a savings card, or another discount plan. Due to rising prescription drug costs, many people struggle to afford their medications and must continually search for ways to save. Here’s some good news: The Rx Advocates offers an affordable and dependable way to fill your prescriptions. We can help you apply for patient assistance programs that guarantee substantial savings. No more searching for a free coupon or skipping doses. We’ll help relieve the financial burden of high medication costs so you can focus on more important things.
Synjardy Cost
$80.00/month
Synjardy Price
$720.1/month
* Source: GoodRx.com
Last updated: September 29, 2025. Actual retail prices may vary by pharmacy and location.
Save more on Synjardy with its patient assistance program
Looking for greater Synjardy savings? Interested to learn how a patient assistance program can help you save more on this brand-name drug? The Rx Advocates is a nationally recognized prescription advocacy program that connects people to the patient assistance programs offered by pharmaceutical manufacturers. These programs offer medications at little or no cost, but unfortunately, most people are unaware they exist or how to apply. This is where our team comes in. We’ll provide affordable access to your prescription medications, whether or not you are insured. Although anyone can apply for patient assistance programs, identifying and applying for those that best suit your needs can be time-consuming and confusing. We help by doing these tasks for you!
People who have worked with us testify they never have to pay hidden fees or additional costs. We charge a one-time enrollment fee of $35. Our monthly service fee then ranges from $80–$110, depending on the number of medications you need financial assistance with. Here’s a look at our pricing model:
- 1 Medication (Synjardy only) – $80 per month
- 2 Medications (Synjardy + 1 other) – $90 per month
- 3 Medications (Synjardy + 2 others) – $100 per month
- 4+ Medications – $110 per month
The Rx Advocates is not a Synjardy XR or Synjardy coupon provider, health insurance plan, or savings card. Instead, we link patients to substantial savings on this brand-name drug through its patient assistance program. And if you take multiple medications, we can help you apply for other patient assistance programs too!
How much does Synjardy cost without a coupon?
As of October 2025, the average retail cost of Synjardy is $synjardy.
Especially for those without health insurance, covering the cost of this prescription medication can be daunting. The price you pay for Synjardy varies based on your location, the pharmacy’s location, the dosage prescribed by your healthcare provider, and whether your insurance plan fully or partially covers prescription medications. These factors make it necessary to compare prices across various pharmacies and can make it difficult for many people to afford this brand-name drug.
We understand how overwhelmed you are by high prescription drug costs, and we can help you access Synjardy and other expensive prescription medications through patient assistance programs, which can save you substantially more than a savings card or free coupon.
How much will it cost with The Rx Advocates?
If approved, by the Synjardy Patient Assistance Program, you’ll be charged a fixed monthly service fee. This fee varies depending on the number of medications you qualify for. For example:
$80 / Month
$90 / Month
$100 / Month
$110 / Month
Do I qualify for Synjardy patient assistance?
- Single and earning less than $40,000 annually
- In a couple whose combined annual income is less than $60,000
- In a larger family with an annual income less than $100,000
Synjardy coupon restrictions
While Synjardy coupons can help reduce the cost of medication, they do have some limitations to consider:
- Depending on your insurance plan, you may be unable to benefit from a free coupon, as some plans do not allow coupon use.
- Coupons can be used only a limited number of times. For example, a coupon may be valid only for the first few purchases, and no coupon can be used past its expiration date.
- Coupons have a limited scope of use. Some are valid only at participating pharmacies, causing frustration for those who do not live near one.
- Coupons may apply only to a certain quantity of medication. Once this limit is reached, patients may have to pay the full price.
- Due to a copay accumulator attached to your insurance plan, a free coupon might not count toward your out-of-pocket maximum. This means you may remain responsible for a significant portion of the cost.
- The savings offered by coupons make little difference when the medication is expensive. For example, if a drug costs $10,000, even a coupon offering 50% off won’t make the medication affordable for the average person.
While a free coupon can provide temporary relief, patient assistance programs offer a more sustainable solution for managing medication costs. The Rx Advocates can help you apply for these programs, gaining you a significant discount on the high cash price of your brand-name drug.
Synjardy uses, drug interactions, and other FAQs
Diabetes is a chronic condition characterized by high blood sugar levels. Having too much glucose in the bloodstream for a long time can cause major problems, such as nerve damage, end-stage renal disease, blindness, urinary tract infections, diabetic ketoacidosis, and cardiovascular disease.
Synjardy and Synjardy XR (extended-release tablets) combine two drugs: empagliflozin and metformin hydrochloride. These medications are used along with diet and exercise to improve glycemic control in people aged ten and older with type 2 diabetes mellitus. People with type 1 diabetes and those experiencing diabetic ketoacidosis should not take it. Synjardy works in multiple ways to control blood glucose: empagliflozin helps the kidneys remove glucose from the bloodstream and has been proven to reduce the risk of cardiovascular death, while metformin lowers blood glucose production in the liver and causes the intestines to absorb less glucose.
Drug interactions affect the way a medication works in the body. Before starting Synjardy, inform your doctor of any other medications you are taking so you can be properly advised to safeguard against harmful interactions. Here are a few drug interactions to consider:
- Concurrent use of Synjardy with insulin or insulin secretagogues (e.g., sulfonylureas) increases the risk of hypoglycemia (i.e., low blood sugar)
- Synjardy can enhance the effects of diuretics, potentially leading to dehydration or electrolyte imbalance
- Drugs that affect kidney function, such as corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs), and ACE inhibitors, can cause sudden kidney problems when used with Synjardy
- Drugs that cause buildup of lactic acid, such as beta-adrenergic agonist inhalers used to treat asthma or COPD (e.g., albuterol and salmeterol), should be avoided when taking Synjardy
Although Synjardy and Synjardy XR have helped many people gain control over their high blood sugar, they are not a good fit for everyone. Some are unhappy with these drugs’ adverse effects, high cash price, or drug interactions. If you are unable to use this drug to treat your type 2 diabetes, here are a few alternatives to discuss with your healthcare provider:
Serious adverse effects of Synjardy
Like all medications, Synjardy can cause adverse effects, some potentially severe. Serious adverse effects associated with Synjardy include the following:
- Lactic acidosis (buildup of lactic acid in the blood), can cause hypothermia, low blood pressure, and sudden cardiovascular death. Symptoms of metformin-related lactic acidosis are usually nonspecific and include malaise, muscle cramps, joint pain, body aches, weakness, lack of energy, difficulty breathing, slow and irregular heartbeat, and stomach pain.
- Diabetic ketoacidosis initially manifests as extreme thirst and frequent urination and, if left untreated, can quickly worsen, causing headache, nausea, vomiting, diarrhea, stomach pain, indigestion, excessive gas, difficulty breathing, lack of energy, muscle pain, low blood sugar, or even coma. It is more common among people with type 1 diabetes or those experiencing other forms of ketoacidosis.
- Severe dehydration causes dizziness, headache, fatigue, weakness, and confusion.
- Serious genital infections, which manifest in females as vaginal odor, white or yellow discharge, and vaginal itch and redness and in males as swelling of the penis (especially in those uncircumcised), redness, itching, pain, rash, and foul-smelling white or yellow discharge.
- Urinary tract infections (a common side effect in those taking empagliflozin) present as a burning sensation when urinating, frequent urination, incontinence, lower stomach or pelvic pain, blood in the urine, fever, and back pain.
- Hypoglycemia (i.e., low blood sugar)can cause headache, drowsiness, weakness, irritability, hunger, fast heartbeat, confusion, tremors, dizziness, sweating, and sudden death.
- Necrotizing fasciitis is a rare but serious condition that initially manifests as a red, warm, swollen, and painful area of skin that quickly spreads and then progresses to fever, malaise, fatigue, nausea, vomiting, diarrhea, ulcers or blisters, and pus oozing from the infected area of skin. If untreated, it can cause septic shock or organ failure. One in five affected people die from this condition.
- Upper respiratory tract infection causes cough, fever, excessive mucus, sneezing, stuffy nose, and sore throat.
- Severe allergic reactions include anaphylaxis; swelling of the face, tongue, or throat; rash; itching; palpitations; trouble swallowing; and difficulty breathing.
Empagliflozin metformin users, especially those with multiple comorbidities (e.g., liver or kidney injury and hypertension), are at high risk of developing serious infections. People taking this drug should maintain a continual dialogue with their healthcare provider and schedule frequent follow-up visits to catch early signs of serious infections and ensure prompt treatment.
Get monthly Synjardy discounts through The Rx Advocates
Tired of the limited savings offered by coupons? Due to the high cash price of prescription drugs, many people are unable to afford their much-needed medications. The Rx Advocates firmly believes that no one should have to choose between purchasing essential medicines and managing their everyday expenses. We understand how overwhelming the high cost of prescription medications can be, especially for those lacking adequate health insurance. Many patient assistance programs can help patients receive their medications at affordable prices, but most people are unaware of them. We understand that the process of applying for these assistance programs is long and confusing, which is why we simplify it for you.
Our team even goes the extra mile, offering the convenience of home delivery of your medications. You won’t need to make trips to the pharmacy or wait in line. Plus, there’s no extra cost for handling refills.
Want to learn more about how The Rx Advocates can help you obtain your monthly prescription medications at affordable prices? Our team is ready to determine your eligibility for the Synjardy or Synjardy XR patient assistance program and for the assistance programs for any other medications you need help acquiring. Contact us today! Maintaining good health does not have to break your bank account.
