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Spravato Coupon & Patient Assistance Programs

Authored by Oto Idah, / Medically Reviewed by Dr. Conor Sheehy, PharmD, BCPS
Last Updated: February 10, 2024

Struggling to afford your monthly Spravato prescription? Navigating the financial challenges of affording your monthly prescription of Spravato can be daunting, especially if you lack insurance coverage. If you’ve been tirelessly searching for a Spravato coupon or a savings card to alleviate the burden, you’re not alone. We recognize the difficulty many individuals encounter in securing affordable access to their essential prescription medicines. At The Rx Advocates, we empathize with the stress and uncertainty that accompany the prospect of paying for Spravato out of pocket. Many patients—including eligible commercially insured patients; those participating in state pharmaceutical assistance programs, the Spravato withMe savings program, or state health insurance programs; and even those who lack coverage—can benefit from our services.

Our mission is to extend a helping hand by guiding you to patient assistance programs offered by pharmaceutical companies, a more robust solution than a simple Spravato coupon. These programs frequently result in more substantial and consistent savings, ensuring that financial constraints don’t hinder your ability to prioritize your health. We make medications like Spravato not only affordable but consistently accessible. The Rx Advocates will support you on your treatment journey.

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Spravato Cost

(using The Rx Advocates)

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30-Day Supply

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Spravato Price

(estimated retail*)

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One Dose Pack

* Source:


How can The Rx Advocates assist with the cost of Spravato?

How can The Rx Advocates lower the cost of Spravato? Navigating the expenses associated with Spravato can be overwhelming. At The Rx Advocates, we understand the financial strain individuals face when seeking treatment with this vital medication. We’re here to provide a solution that goes beyond traditional methods. The Rx Advocates does not offer a Spravato coupon or discount card; instead, we specialize in connecting patients to over 100 pharmaceutical manufacturers’ patient assistance programs. We take pride in being the nation’s leading prescription advocacy program, facilitating access to more than 800 FDA-approved medications, including Spravato, and the top 100 prescribed drugs in the United States. We’re committed to making the process stress-free, ensuring that individuals have a seamless experience securing the assistance they need.

Unlike a coupon, insurance plan, or discount card, The Rx Advocates acts as your dedicated partner in navigating the complexities of patient assistance programs. Our expertise lies in managing the application process, liaising with healthcare providers, and diligently following up with pharmaceutical companies. And we don’t stop at approval; we continue to support you by managing your refills, ensuring you never go without your prescription.

Are there disadvantages to using a Spravato coupon?

While Spravato coupons can offer immediate relief on prescription costs, it’s crucial to consider potential limitations.

Limited acceptance

Spravato coupons often come with restrictions on where and how they can be used. Some may be valid only at specific pharmacies or for a limited duration, limiting a patient’s flexibility.

Copay accumulators

If your insurance plan employs a copay accumulator program, using a Spravato coupon might not contribute toward your out-of-pocket maximum. This means even with the coupon, you may be responsible for the full cost of the medication.

Expiration dates

Spravato coupons typically have expiration dates, after which they become invalid.

Insurance coverage limitations

Even with a coupon, the expense of Spravato may remain high, especially if insurance coverage is limited. Patients may find themselves shouldering a significant portion of the cost out of pocket.

An alternative to Spravato coupons

While Spravato coupons offer some immediate relief, patient assistance programs provide sustainable, long-term savings. The Rx Advocates specializes in connecting individuals to these programs, ensuring continual access to Spravato at an affordable price. We guide you through the application process, helping you qualify for these programs. We care about your health and financial well-being, and we’re here to make accessing essential medications like Spravato easier for you.

The cost of Spravato with The Rx Advocates

Let’s talk about cost. Our pricing model is transparent and designed to ease your financial concerns. For Spravato, the monthly fee is a fixed $80. This fee remains consistent, regardless of fluctuations in the retail price of the medication. If you need assistance with multiple medications, we offer a tiered pricing structure.

  • 1 Medication (Spravato only) – $80 per month
  • 2 Medications (Spravato + 1 other) – $90 per month
  • 3 Medications (Spravato + 2 others) – $100 per month
  • 4+ Medications – $110 per month

Rest assured, there are no hidden fees. The Rx Advocates is dedicated to providing a reliable and affordable solution for accessing Spravato and other essential medications. We’re here to make a meaningful difference in your healthcare journey. The most you’ll ever pay for four or more medications is $110 per month.

How much does Spravato cost?

As of January 2024, the average retail Spravato cost is $784.00.

This cost is determined by an interplay of factors that contribute to the mosaic of prescription pricing. Navigating these variables can be daunting, and the financial strain can be overwhelming.

Dosage prescribed by your healthcare provider

The dosage of Spravato prescribed by your healthcare provider significantly impacts its cost. Higher doses generally come with higher price tags.

Patient location

Geographical factors play a crucial role in determining the cost of Spravato. Your location can influence both pricing structures and overhead costs.

Pharmacy location

Different regions and pharmacies have distinact pricing, contributing to fluctuations in the cost of Spravato.

Health insurance coverage

Whether or not you have health insurance that covers prescriptions is a pivotal factor in medication costs. Comprehensive insurance plans often result in lower out-of-pocket expenses, while individuals without coverage may have to pay the full retail price of Spravato.

Lowering the cost of Spravato

Navigating these factors can be complex, and many individuals face high out-of-pocket costs for essential medications like Spravato. At The Rx Advocates, we recognize these challenges and offer a solution. By connecting individuals to patient assistance programs from over 100 pharmaceutical manufacturers, we aim to alleviate the financial burden associated with Spravato, making it more accessible and affordable. Our mission is to ensure that individuals can prioritize their mental health without the constraints of prohibitively high medication costs. If approved, you can access Spravato for a fixed monthly fee, starting at just $80.


How much will it cost with The Rx Advocates?


How much will it cost with The Rx Advocates?

If approved, by the Spravato Patient Assistance Program, you’ll be charged a fixed monthly service fee. This fee varies depending on the number of medications you qualify for. For example:

1 Medication

$80 / Month

2 Medications

$90 / Month

3 Medications

$100 / Month

4 Medications

$110 / Month

1 Medication

$80 / Month

2 Medications

$90 / Month

3 Medications

$100 / Month

4 Medications

$110 / Month

NOTE: In addition to our monthly service fee, we charge a one-time enrollment fee of $35. Our service is month-to-month, so if you’re not happy with it, you may cancel at any time.

Am I qualified for the Spravato patient assistance program?

To qualify for services with The Rx Advocates and potentially benefit from patient assistance programs, individuals must meet specific income criteria. Eligible patients seeking assistance for Spravato will meet one of the following eligibility requirements:
  • Individuals earning up to $40,000 annually
  • Couples earning up to $60,000 annually
  • Large families earning up to $100,000 annually

These criteria serve as guidelines, as they vary across programs and may be adjusted to recognize the diverse financial situations of individuals and families.

At The Rx Advocates, we understand that managing the cost of essential medications like Spravato can be challenging. Our mission is to bridge financial gaps to make these medications more accessible. We encourage those in need to reach out to us directly so we can evaluate their specific situation and provide personalized assistance. Your health and well-being are our priorities, and we are here to help navigate your path to affordable Spravato and other vital medications.

What is Spravato used for?

Spravato, active ingredient esketamine, is a groundbreaking medication primarily prescribed to treat adults with treatment-resistant depression (TRD) and major depressive disorder (MDD). This prescription nasal spray marks a significant advancement in the realm of mental health treatment, offering hope to individuals who have not responded adequately to other antidepressant medications.

Spravato’s mechanism of action

Spravato is the only FDA-approved nasal spray for adult patients with two forms of challenging-to-treat MDD. These include adults with MDD who have responded inadequately to two or more oral antidepressants, a condition known as treatment-resistant depression (TRD), and adults with MDD experiencing suicidal thoughts or actions. Spravato works by antagonizing the N-methyl-D-aspartate (NMDA) receptors in the brain, impacting the neurotransmitter glutamate. This mechanism distinguishes Spravato from conventional antidepressants, providing a unique approach for those who respond poorly to traditional treatments.

Secondary uses

Beyond its primary use in treating MDD, Spravato shows potential for addressing other mental health conditions, such as bipolar depression and post-traumatic stress disorder (PTSD). While these applications are still under exploration, the evolving landscape of psychiatric medicine is showing promise for Spravato’s versatility.

Forms and dosages

Spravato is available as a nasal spray, allowing for a non-intrusive administration. Dosages are carefully titrated based on individual patient responses and needs. Precise dosing ensures a tailored approach to treatment, enhancing the medication’s efficacy while minimizing potential adverse effects.

Adverse effects and interactions

Common side effects of Spravato include dissociation, dizziness, nausea, and increased blood pressure. When used along with an oral antidepressant, Spravato can cause users to feel disconnected from their thoughts, feelings, and things around them. It can also cause decreased tactile sensitivity (numbness), anxiety, lack of energy, vomiting, and feelings of drunkenness, excitement, or extreme happiness. If these common adverse effects occur, they usually appear shortly after starting Spravato and resolve the same day. However, individual responses vary, and not everyone will experience these effects. It is also vital to understand Spravato’s potential drug interactions, especially with central nervous system depressants, to achieve a comprehensive approach to patient care.


Understanding Spravato’s mechanism of action, primary and potential secondary uses, available forms and dosages, and associated side effects and drug interactions is essential for both healthcare providers and patients. This knowledge empowers informed decision-making, facilitating a personalized and effective approach to mental health treatment. As with any medication, open communication with healthcare professionals ensures the best possible outcomes and contributes to the ongoing advancement of mental health care.
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