Safyral Patient Assistance Program

Medically Reviewed by Dr. Conor Sheehy, PharmD, BCPS
Last Updated: October 31, 2025

Birth control should be straightforward. You need reliable contraception, and your gynecologist recommended Safyral because it includes folate supplementation alongside pregnancy prevention. The added folate helps protect against neural tube defects if you become pregnant unexpectedly, which made sense as part of your reproductive health plan. Then you learned what it costs each month without adequate insurance coverage, and suddenly a routine prescription became a budget problem.

The Rx Advocates connects women with Patient Assistance Programs (PAPs) that provide birth control at income-based costs rather than forcing you to choose between contraception and other expenses.

What is the Safyral Patient Assistance Program?

Pharmaceutical manufacturers fund programs for women needing contraception who meet income eligibility thresholds. These programs provide Safyral at reduced rates to qualifying applicants, ensuring financial constraints don’t prevent access to reliable birth control.

You submit prescription documentation and income verification. Our staff assembles your application, coordinates with your gynecologist, files everything with the manufacturer, and tracks approval status. After enrollment, Safyral arrives at your address monthly.

We work as a prescription advocacy service connecting women nationwide with manufacturer programs that determine medication costs based on household income rather than pharmacy retail pricing.

How to Qualify

Program acceptance depends on household income and valid prescription:

  • Singles earning less than $40,000 yearly
  • Couples whose combined annual income is less than $60,000
  • Larger families with annual income of less than $100,000
  • Valid prescription from licensed healthcare provider

Even if you meet these requirements, approval isn’t guaranteed. The eligibility criteria for patient assistance vary across programs. Don’t hesitate to reach out to us to find out if you qualify.

Pricing

Cost of Safyral
with The Rx Advocates

The monthly service fee depends on the number of medications you take. For example:

1 Medication

$80 / Month

2 Medications

$90 / Month

3 Medications

$100 / Month

4 Medications

$110 / Month

NOTE: In addition to our monthly service fee, we charge a one-time enrollment fee of $35.
Our service is month-to-month, so if you’re not happy with it, you may cancel at any time.

The Rx Advocates Can Help Reduce Safyral Costs

You’ll pay a fixed monthly fee based on the total number of medications requiring assistance. That fee never increases when retail prices change.

Birth control is ongoing, not temporary. Our service helps women across different insurance circumstances: those with plans that exclude contraceptive coverage, high deductibles that make prescriptions expensive, or no insurance at all.

We don’t provide coupons or discount programs. We handle enrollment in pharmaceutical company programs that supply ongoing contraception at costs substantially below retail.

Cost of Safyral vs Other Options

The Rx Advocates logo w text alt 5
Safyral Cost
(using The Rx Advocates)
Dollar sign logo
30-Day Supply
$80.00/month
Goodrx logo
Safyral Price
(estimated retail*)
Dollar sign logo
One Dose Pack
$262.99

* Source: GoodRx.com

Last Updated: September 29, 2025. Actual retail prices may vary by pharmacy and location.

Why Patient Assistance Programs Beat Coupons

Coupons give short-term help. Patient assistance programs deliver lasting support.

Coupon limitations

  • Pharmacy restrictions: Only accepted at certain locations
  • Copay accumulators: May not apply toward your deductible
  • Expiration dates: Limited validity period
  • Coverage gaps: Often insufficient when medication costs are high
  • Redemption requirements: Physical presentation at pharmacy needed

PAP advantages

  • Substantial savings: Far exceed typical coupon discounts
  • Reliable access: Consistent availability without expiration concerns
  • Predictable costs: Your fee stays the same regardless of price changes
  • Convenient delivery: Medication ships directly to you

Frequently Asked Questions (FAQ)

We’ve compiled answers to some of the most common questions about Safyral and patient assistance programs.

With The Rx Advocates, patients pay a fixed monthly service fee, which depends on the number of medications covered.

  • 1 Medication (Safyral only) – $80 per month
  • 2 Medications (Safyral + 1 other) – $90 per month
  • 3 Medications (Safyral + 2 others) – $100 per month
  • 4+ Medications – $110 per month

Importantly, there are no hidden fees, and prices remain consistent even if retail costs fluctuate.

Without a patient assistance program, Safyral is expensive. Retail pricing fluctuates based on variables women cannot control.

Several factors influence the final price a patient may pay:

  • Dosage: Higher prescribed strengths or quantities cost more
  • Location: Prices vary by region due to healthcare and pharmacy pricing differences
  • Pharmacy: Each pharmacy sets its own retail structure, which can cause major variations
  • Insurance Coverage: Patients with commercial insurance may pay less, while those without coverage often face the full retail cost

This means that two patients could pay very different amounts for the same prescription, depending on where they live, where they buy their medication, and their insurance status.

Most patients meet the requirements when annual household income stays below $40k for individuals, $60k for couples, or $100k for larger families. Since manufacturer requirements can differ, The Rx Advocates assess each case individually to determine eligibility.

The Rx Advocates manage enrollment and monthly refills, coordinating all necessary paperwork with your prescribing physician, submitting completed applications to manufacturers, and arranging medication deliveries to prevent treatment interruptions.

About Safyral

Safyral is a combination oral contraceptive containing drospirenone, ethinyl estradiol, and levomefolate calcium used to prevent pregnancy.

How it works: Safyral prevents pregnancy through multiple mechanisms: stopping ovulation, thickening cervical mucus to block sperm, and thinning the uterine lining. The included folate helps maintain adequate folate levels, which reduces risk of neural tube defects if pregnancy occurs despite contraception.

Administration: Taken orally once daily at the same time each day. The pack contains 28 tablets including active hormone pills and reminder pills. Consistent timing maximizes effectiveness.

Side effects:

  • Common: Nausea, breast tenderness, headache, mood changes, irregular bleeding
  • Serious: Blood clots, stroke, heart attack, high blood pressure, liver problems

Important warnings: Safyral carries increased risk of blood clots, particularly in women who smoke, are over 35, or have clotting disorders. Do not use if you have a history of blood clots, stroke, heart problems, or certain cancers. Inform your doctor about all medications you take as some drugs reduce contraceptive effectiveness. Contact your doctor immediately if you experience chest pain, severe headache, vision changes, or leg swelling.

Get Started Today

Contraception gives you control over your reproductive choices and future planning. When cost becomes a barrier, many women end up skipping doses or going without birth control entirely, which defeats the purpose of having a prescription in the first place.

Pharmaceutical companies allocate significant funding specifically for contraceptive assistance programs. The application process exists to verify eligibility, not to exclude people who genuinely need help affording their medications.

Contact us today to learn how patient assistance programs can help you afford Safyral treatment.

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