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Estring Coupon & Patient Assistance Programs

Authored by Monique Deluge, / Medically Reviewed by Dr. Conor Sheehy, PharmD, BCPS
Last Updated: June 13, 2024

Finding it challenging to cover the cost of your monthly Estring prescription? Tired of the limited savings offered by an Estring coupon or copay program? Estring is a form of local estrogen therapy used to treat moderate to severe menopausal symptoms, including vaginal atrophy. However, as prescription drug costs steadily rise, many people find it difficult to afford this medication. Those who lack an adequate health insurance plan may even have to cover its entire cost. If you are struggling to pay for this prescription medication, you are certainly not alone. You may have looked for an Estring coupon, savings card, or copay program to cut costs, only to discover these barely made a difference. But there is a solution! Patient assistance programs are much more reliable ways to secure significant and enduring savings.

At The Rx Advocates, we go beyond coupons and savings cards to help individuals save significantly on their prescription drugs by connecting them with these patient assistance programs. If you need help paying for Estring, you have come to the right place! Our team is dedicated to providing personalized assistance to get you the medications you need at prices you can afford.

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Estring Cost

(using The Rx Advocates)

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30-Day Supply

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Estring Price

(estimated retail*)

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One Dose Pack

* Source:


Access the Estring patient assistance program with the Rx Advocates

Overwhelmed by a high Estring cost? Need a discount? The Rx Advocates is a nationally recognized prescription advocacy service that helps people, whether or not they have private insurance coverage, apply for financial assistance through patient assistance programs. These programs are offered by pharmaceutical companies to help people afford their products, and they guarantee much greater savings than a coupon. Sadly, however, most people are unaware they exist and thus miss out on substantial savings. Moreover, the application process is long and can be confusing, prompting many people to give up before they get approved. We can link you to the Estring patient assistance program, and if you need help paying for other prescriptions, we can help you access their programs as well.

Our pricing model is simple and transparent. What you see is what you get; there are no hidden costs or additional fees. Eligible patients pay a one-time enrollment fee of $35 and then a fixed monthly service fee of just $80–$110, depending on the number of medications they receive: 

  • 1 Medication (Estring only) – $80 per month
  • 2 Medications (Estring + 1 other) – $90 per month
  • 3 Medications (Estring + 2 others) – $100 per month
  • 4+ Medications – $110 per month

Here’s some more great news: because The Rx Advocates is not a prescription discount card or health insurance plan, our pricing remains consistent, even if the retail price of your medication increases. Our service is also month to month, so if you’re unhappy with it, you may cancel at any time. With us, you’re never alone in your efforts to afford prescription medications.

How much does Estring cost?

As of April 2024, the average retail cost of Estring is $660.26.

Most people find it difficult to cover such a high cost without the aid of copay payment plans, savings cards, coupons, or other discounts, but even these methods often can’t make this medication affordable.The price one pays for Estring varies based on several factors. One major factor is the varying cost of living across regions of the country. Other factors include the prescribed dosage, the pharmacy’s location, and the extent to which the patient’s private insurance plan covers prescription medications.

Our team at The Rx Advocates understands the frustration of being unable to access medications due to lack of funds. Because we believe everyone—regardless of income—deserves access to good healthcare, our goal is to help as many eligible patients as possible access their essential drugs through the financial aid offered by patient assistance programs.


How much will it cost with The Rx Advocates?


How much will it cost with The Rx Advocates?

If approved, by the Estring Patient Assistance Program, you’ll be charged a fixed monthly service fee. This fee varies depending on the number of medications you qualify for. For example:

1 Medication

$80 / Month

2 Medications

$90 / Month

3 Medications

$100 / Month

4 Medications

$110 / Month

1 Medication

$80 / Month

2 Medications

$90 / Month

3 Medications

$100 / Month

4 Medications

$110 / Month

NOTE: In addition to our monthly service fee, we charge a one-time enrollment fee of $35. Our service is month-to-month, so if you’re not happy with it, you may cancel at any time.

Am I eligible for the Estring patient assistance program?

To qualify for most patient assistance programs with The Rx Advocates, people must meet one of the following criteria:
  • For singles, you earn less than $40,000 annually
  • For couples, your combined annual income is less than $60,000
  • For larger families, your annual household income is less than $100,000
Eligibility criteria vary across programs, however, and are generally designed to make patient assistance programs accessible to those who need them most. Without adequate health insurance coverage, many across the US face the daily dilemma of choosing between paying for everyday expenses and for their much-needed prescription drugs. Contact us today to see if you meet the criteria for assistance!

Estring coupon limitations

Although Estring coupons can provide some savings, they are not a reliable way to save money, as they come with several limitations:

  • Coupons often have limited time frames for use and/or expiration dates, which means they might not offer a discount when you need it.
  • Some coupons can only be used once or cap the number of refills you can receive at discount.
  • Some pharmacies do not accept coupons, and  some insurance plans don’t permit them to count toward an out-of-pocket maximum. In such cases, you may remain responsible for the full cost of the medication.
  • Coupons often have a limited scope of use. For example, some apply only to certain brand names or products from certain pharmaceutical companies.
  • The savings offered by coupons make little difference when the medication is expensive. For example, if a drug costs $10,000, even a coupon offering 50% off won’t make the medication affordable for the average person.

Instead of depending on coupons, explore the advantages of patient assistance programs that offer long-lasting savings and a more dependable way to manage your prescription costs. The Rx Advocates can help you apply for these programs, freeing you from the continual search for a valid Estring coupon.

Estring uses, alternatives, precautions, and other FAQs

Estring is a prescription medication used as hormone replacement therapy for postmenopausal women. It is a small, white, flexible ring that is placed in the upper third of the vagina. The center of the ring contains estrogen, which is released into the vagina consistently for 90 days. If continued therapy is needed, another ring can be placed after 90 days.

Estrogen performs many functions in the female body. During menopause, the level of this vital hormone decreases, causing many bodily changes. Some lucky women experience few or no symptoms, but others suffer symptoms that interfere with their lives, such as heavy or unusual vaginal bleeding, hot flashes, incontinence, and vaginal yeast infection. Estring works as local estrogen therapy that specifically targets menopausal changes in the vagina.

You and your doctor should communicate regularly to develop and maintain a health plan that ensures safe use and effective use of this hormonal therapy.

DO NOT start Estring if any of the following apply to you:

  • Unusual vaginal bleeding, as vaginal bleeding in postmenopausal women may be a sign of uterine cancer. You must determine the cause of bleeding before beginning any estrogen therapy.
  • A history of cancer, as estrogen therapy is linked to increased incidence of certain cancers, including breast cancer.
  • A history of stroke, heart attack, blood clots, bleeding disorders, or liver disease.
  • Breastfeeding or pregnant.
  • Abnormal vision caused by damage to blood vessels in the eyes.
  • A diagnosis of porphyria, as hormonal therapy will worsen symptoms.

If you are unable to use Estring, here are a few alternative medications you can discuss with your doctor:

Adverse effects of Estring

Common adverse effects of Estring

Some common and mild adverse effects of Estring include the following:

  • Increased vaginal discharge
  • Headache
  • Dizziness
  • Bloating
  • Nausea and vomiting
  • Vaginal yeast infection

Severe and rare adverse effects of Estring

Though rare, some women experience more serious adverse effects after starting treatment with Estring. Contact your doctor if you notice any of the following unusual signs and symptoms:

  • Breast pain, enlarged breasts, or new breast lumps
  • Unusual vaginal bleeding
  • Difficulty speaking
  • Changes in vision
  • Darkening of skin on the face
  • Intense headache
  • Memory loss or confusion
  • Weakness or numbness in the arms or legs

Estring can also cause the following severe side effects that can become life-threatening without immediate medical attention:

  • Severe abdominal pain, which can be a sign of liver disease, gallbladder issues, or enlargement of benign uterine tumors (i.e., fibroids)
  • Heart attack, which includes symptoms such as chest pain, cold sweat, fatigue, sudden lightheadedness, and nausea
  • Stroke, which can cause severe headache, slurred speech, numbness on one side of the body, loss of balance, confusion, and vision changes
  • Blood clots, which can cause chest pain, calf pain or tenderness, difficulty breathing, and dizziness
  • Depression, which may manifest as exaggerated sadness, hopelessness, lack of interest in previously enjoyed activities, distancing from friends and family, and/or alcohol abuse
  • Early onset dementia, which includes memory loss, frequent confusion, personality or behavior changes, depression, and decreased ability to complete simple tasks without help
  • Cancer of the breast, ovaries, or uterus
  • High blood pressure
  • Allergic reactions, which can cause hives, swelling of the vagina, vaginal discomfort, and itching
  • Toxic shock syndrome, which has symptoms such as fever, nausea, vomiting, muscle pain, dizziness, fainting, and body rash

It is also important to note that Estring may become stuck, causing erosion and/or perforation of the vaginal wall and requiring surgical removal.

Get Estring discounts every month through The Rx Advocates

At The Rx Advocates, our goal is to help people get the monthly medications they need at prices they can afford. Patient assistance programs offer tremendous benefits to those struggling to keep up with rising prescription drug costs, whether or not they have health insurance.

Here’s an added convenience: you won’t need to make trips to the pharmacy because we arrange for home delivery. We also handle refills at no extra charge. If you’re wondering how The Rx Advocates can maximize your savings each month by making expensive medications like Estring more affordable, contact us. Our team is here to determine your eligibility, so speak to one of our representatives today!

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