Ozempic Side Effects: A Comprehensive Guide

Ozempic Side Effects: A Comprehensive Guide

Authored by Oto Idah, / Medically Reviewed by Dr. Conor Sheehy, PharmD, BCPS
Last Updated: October 27, 2023


Ozempic, the brand name for the prescription medication semaglutide, is a versatile medication primarily used to manage type 2 diabetes in adults and achieve weight loss. The brand name formulated for weight loss only is called Wegovy.

In adults with type 2 diabetes with a documented history of heart disease, Ozempic may lower the likelihood of significant cardiovascular incidents like heart attacks, strokes, or fatalities. Ozempic is typically administered as a once-weekly injection and is intended to be used alongside a proper diet and exercise program. The safety and efficacy of Ozempic is not known in children under 18. Ozempic should not be prescribed for type 1 diabetes and should only be used under the guidance of a healthcare professional.

What is Ozempic Used For?

Ozempic and Diabetes

Ozempic stimulates insulin release from the pancreas and reduces the amount of glucose the liver produces. It also slows down digestion, which can help regulate blood sugar levels after meals and improve glycemic control.

Ozempic and Weight Loss

Ozempic has a secondary benefit of promoting weight loss by reducing hunger and food cravings and increasing satiety, which is especially beneficial for individuals who need to lose weight to manage their diabetes better.

The Importance of Understanding Ozempic Side Effects

Always discuss the risks and benefits of Ozempic or any other medication with your healthcare provider and promptly report any unusual or severe side effects. Understanding the potential side effects of Ozempic or any medication is crucial for several reasons:

Safety: Some Ozempic side effects can be serious and require prompt medical attention.

Patient Compliance: Knowing the possible side effects of Ozempic can improve compliance with the prescribed treatment plan and lower the likelihood of discontinuing the medication.

Monitoring and Reporting: Healthcare providers can monitor patients taking Ozempic for specific side effects during treatment. Early detection and intervention are essential for their safety if a patient experiences a rare or severe side effect.

Side Effects of Ozempic (Semaglutide)

The questions on the minds of many are, “Is Ozempic a high-risk medication?”, “What are the common side effects of Ozempic?” and “What are the long-term effects of Ozempic?” If you are already taking Ozempic or planning to start, here is what you need to know about the side effects of this medication. Some side effects are common and mild, while others are rare, unique, and sometimes very severe. Ozempic can also cause long-term side effects in some people, which may persist even after they stop taking the medication.

Common Side Effects of Ozempic

The common side effects of Ozempic can vary from person to person, but they typically include:

  • Nausea: This is one of the most frequently reported side effects of Ozempic. It can occur when medication starts but often lessens over time as the body adjusts. Eating bland, low-fat foods and soups can help alleviate nausea. Also, eat slowly, avoid fried or greasy foods, do not lie down immediately after eating, and go outside for fresh air to improve the symptoms.
  • Stomach Pain: Some individuals may experience abdominal discomfort or stomach pain. This side effect is usually mild and temporary.
  • Constipation: Ozempic can slow down stomach emptying, which may lead to constipation. Adequate hydration and dietary fiber intake can help alleviate this issue.
  • Diarrhea: While less common than constipation, diarrhea can occur as a side effect. If diarrhea persists or becomes severe, please consult a healthcare provider immediately.
  • Hypoglycemia: Ozempic can lower blood sugar levels, potentially leading to hypoglycemia (low blood sugar). Monitor your blood sugar levels closely, particularly if you also take other medications that can lower your blood sugar. Eat or drink something sugary as a quick way to raise your blood sugar back up. Glucose tablets/gels can help too.
  • Injection Site Reactions: Redness, itching, or pain at the injection site are possible side effects. Rotate your injection sites and ensure proper injection technique to minimize these reactions.
  • Headaches: One of the potential side effects of Ozempic is headaches. Clinical trial findings do not list headaches as a side effect; rather, they are usually linked to nausea, hypoglycemia, or other side effects. You may experience mild to moderate headaches, especially during the initial weeks of treatment. These headaches typically subside as the body adjusts to the medication. However, if headaches persist or become severe, it is important to consult with a healthcare provider.

Other common side effects include bloating, gas, reflux, heartburn, runny nose, flu-like symptoms, dizziness, and tiredness. Generally, to manage common side effects of Ozempic, you have to be patient, as many of these side effects tend to improve over time as your body adapts to the medication.

In addition, follow your healthcare provider’s recommendations regarding the dosage and administration of Ozempic. It is crucial to communicate openly with your healthcare provider about any side effects you experience while taking Ozempic so they can provide guidance, adjust your treatment plan if necessary, or suggest alternative medications if the side effects are severe or persistent.

Rare, Severe, and Long-Term Side Effects of Ozempic

Although this is relatively rare, Ozempic may increase the risk of acute and chronic pancreatitis, a potentially serious inflammation of the pancreas. Severe abdominal pain, nausea, and vomiting may indicate that you have pancreatitis. Seek immediate medical attention if any of these symptoms occur and persist. Your healthcare provider may advise you to discontinue Ozempic if pancreatitis is confirmed.

Other severe side effects of Ozempic include the risk of thyroid tumors and cancer, diabetic retinopathy complications, acute kidney injury, worsening kidney failure, severe hypersensitivity reactions, changes in vision/worsening eyesight, skin reactions or rashes, rapid heartbeat, and gallbladder disease. In addition, although not mentioned on the drug label and research has not yet found a link, people taking Ozempic have reported mental health side effects such as increased anxiety, depression, suicidal thoughts, and vivid dreams. Hair and muscle loss have been reported when taken as Wegovy for weight loss.

There are ongoing studies to assess the medication’s safety over extended periods. Potential long-term concerns include bone health, as some diabetes medications have been linked to a higher risk of fractures. Regular bone density monitoring may be advisable for those on long-term Ozempic therapy.

Please report adverse side effects by visiting www.fda.gov/medwatch. You can also call 1-800-FDA-1088.

Ozempic Weight Loss Side Effects

One notable effect of Ozempic is that some people experience weight loss. Moreover, Wegovy, a higher-strength version of Ozempic, is FDA-approved for weight loss in adults and teenagers. The weight loss benefits of Ozempic are often considered a positive outcome, especially for those with diabetes who may also struggle with weight management.

Side Effects Related to Weight Loss

Besides gastrointestinal symptoms like nausea, vomiting, diarrhea, and stomach discomfort, several other side effects related to weight loss have been reported.

  • Ozempic Face: People on Ozempic may look older and gaunt, with sagging skin and wrinkles most visible on the face. There is no direct evidence to suggest Ozempic ages your face, causes premature aging, or changes your appearance in any way. However, rapid weight loss can lead to loss of facial fat, giving the face the gaunt appearance termed “Ozempic Face.” Adequate skin care management may help mitigate this effect. Your healthcare provider can also suggest specific treatments to improve your appearance.
  • Muscle Loss: Experts note that Ozempic/Wegovy can cause up to 40% lean muscle mass loss, which is worrisome. Engaging in strength-building exercises and eating sufficient high-quality protein may help preserve muscle mass during weight loss.
  • Hair Loss: This side effect is not listed on Ozempic’s FDA label but is listed on Wegovy’s. However, research shows this is not unique to Ozempic, as rapid weight loss by any method causes hair loss. The good news is that new hair eventually grows out.
  • Fatigue: Ozempic may cause fatigue, extreme tiredness, and weakness that is not eased by sleep. This is linked to the fact that Ozempic severely inhibits appetite and food cravings, leading to an extreme calorie deficit that causes low energy levels and fatigue. This is nothing to worry about unless it becomes debilitating. Your body should adjust as it adapts to your diet and calorific changes.
  • Rebound Weight Gain: As with other weight loss methods, you may regain some or all the weight lost if you stop taking Ozempic or Wegovy. Establishing healthy eating habits can help you maintain your weight loss in the long term.

How quickly do you lose weight on Ozempic?

The rate at which individuals lose weight on Ozempic can vary. Some may experience rapid weight loss, while others may see gradual progress over time. It is crucial to manage expectations and consult with a healthcare provider about your weight loss goals and any side effects you may be experiencing. They can help you navigate the process, adjust your treatment if necessary, and provide guidance on maintaining a healthy and sustainable weight loss journey. Remember that weight loss should always be pursued in a balanced and healthy manner.

Taking Ozempic While Pregnancy or Breastfeeding

Animal studies indicate adverse effects on pregnancy, but there is limited information about its safety in humans during pregnancy. Breastfeeding individuals should also avoid Ozempic, as it may pass into breast milk and potentially affect the nursing infant.

Precautions and Alternatives for Pregnant Individuals

Healthcare providers typically recommend managing blood sugar levels with insulin, which has a long history of safe use during pregnancy. Alternative medications and lifestyle modifications may also be considered on a case-by-case basis, but the primary goal is to ensure a healthy pregnancy and minimize risks to both the mother and the baby. Please consult your healthcare provider before starting, stopping, or continuing Ozempic if you are trying or have become pregnant or breastfeeding to ensure your well-being and that of your baby.

Dosage and Overdose: What Happens if You Take Too Much Ozempic?

Recommended Dosage

The typical starting dose of Ozempic for managing type 2 diabetes is 0.25 mg once a week for about four weeks, usually administered as a subcutaneous injection with or without meals. This dose is not usually effective for glycemic control; it is only intended for treatment initiation. Depending on individual response, the dosage may be increased to 0.5 mg, then 1 mg, then 2 mg, every four weeks. The maximum recommended dosage is 2 mg per week. It is essential to follow your healthcare provider’s prescribed dosage and administration instructions.

Ozempic Overdose Side Effects

Taking more Ozempic than prescribed can lead to hypoglycemia (low blood sugar) or gastrointestinal side effects, such as nausea, vomiting, and diarrhea. Severe hypoglycemia can result in symptoms like confusion, dizziness, sweating, and loss of consciousness and can be a medical emergency requiring prompt treatment. You may need to consume a source of sugar, such as glucose tablets, fruit juice, or non-diet soda, to raise your blood sugar levels. Also, contacting a healthcare professional or visiting the nearest emergency room for further evaluation and management is crucial.

If you suspect an overdose of Ozempic, seek immediate medical attention or call the Poison Help line at 1-800-222-1222.

What if I miss my Dose?

If you miss a dose of Ozempic, take it as soon as possible, within five days. If it exceeds five days, skip the missed dose and resume your regular dosing schedule.

Tips for Safe Usage and Avoiding Overdose

  1. Always follow your healthcare provider’s instructions regarding the dosage and administration of Ozempic.
  2. Monitor your blood sugar levels regularly as directed by your healthcare provider.
  3. Carry a source of fast-acting sugar (like glucose tablets) with you in case of hypoglycemia.
  4. Inform your healthcare provider about all other medications you are taking, as some drugs may interact with Ozempic.
  5. Educate yourself about the signs and symptoms of hypoglycemia to recognize and manage low blood sugar promptly.

Can I Stop Taking Ozempic Suddenly?

It is generally not recommended to stop taking Ozempic abruptly without consulting your healthcare provider. Doing so can lead to disruptions in blood sugar control.

Ozempic Withdrawal Symptoms

There are no specific withdrawal symptoms associated with Ozempic. However, discontinuing the medication without proper planning and alternative management can raise your blood sugar uncontrollably and exacerbate the symptoms of diabetes.

Will I Gain Weight Back if I Stop Using Ozempic?

Weight management can be a concern when discontinuing Ozempic. When you stop taking it, you may experience increased appetite, which could lead to weight gain. However, the extent of weight regain varies among individuals and may depend on factors like diet, exercise, healthy habits, and genetics.

Tips for Safely Discontinuing Ozempic and Maintaining Weight

  1. Always consult your healthcare provider before discontinuing Ozempic to develop a plan for transitioning to an alternative treatment or management strategy.
  2. Focus on a balanced diet and regular physical activity to help maintain your weight and blood sugar control.
  3. Monitor your blood sugar levels closely after discontinuation and work with your healthcare provider to adjust your diabetes management plan as needed.
  4. Consider other diabetes medications or lifestyle modifications to support weight management and blood sugar control.
  5. Seek guidance from a registered dietitian or diabetes educator for personalized strategies to maintain a healthy weight.

Frequently Asked Questions About Ozempic Side Effects

How Long Can You Stay on Ozempic?

The use duration depends on your health needs and response to the medication. Some people may use it for an extended period, while others may switch to different treatments as their condition evolves. Always follow your healthcare provider’s recommendations regarding the duration of Ozempic therapy.

Why Do People Stop Using Ozempic?

People may discontinue Ozempic for various reasons, including the desire to explore alternative treatments, side effects, cost, or achieving their diabetes management goals. Communicating openly with your healthcare provider if you are considering discontinuing the medication is crucial, as they can help you make informed decisions.

Is Ozempic a High-Risk Medication?

Ozempic is generally considered safe when used as prescribed. Like all medications, it carries potential side effects and risks. However, the benefits of improved blood sugar control often outweigh the risks. Your healthcare provider can assess your specific health profile to determine whether Ozempic is suitable for you.

What Makes Ozempic Side Effects Worse?

Certain factors, such as improper dosing, interactions with other medications, or underlying health conditions, can exacerbate Ozempic’s side effects. It is crucial to take the medication as directed and inform your healthcare provider of all other drugs and supplements you are taking to minimize the risk of adverse reactions.

What Should I Avoid While Taking Ozempic?

While on Ozempic, you should avoid excessive alcohol consumption, as it can increase the risk of hypoglycemia (low blood sugar). Additionally, be cautious about driving or operating heavy machinery if you experience dizziness or low blood sugar symptoms while taking Ozempic. Always follow your healthcare provider’s advice on lifestyle choices and precautions while using the medication.


Ozempic can effectively manage type 2 diabetes and obesity, but it is not without potential side effects. Maintaining open communication with your healthcare provider if you are considering or currently using Ozempic is essential. By doing so, they can work with you to monitor and manage any side effects that may arise, make informed decisions about treatment duration, and ensure that the benefits of improved blood sugar control outweigh any associated risks. Remember that the experience of side effects can vary from person to person, and healthcare providers are there to provide guidance and support you throughout your treatment journey. Taking Ozempic as prescribed and being vigilant about your blood sugar levels can also help you use the medication safely and effectively while minimizing the risk of overdose.

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