Basaglar vs. Lantus: Understanding the Differences

Authored by The Rx Advocates, / Medically Reviewed by Dr. Conor Sheehy, PharmD, BCPS
Last Updated: August 14, 2023


If you’ve been diagnosed with diabetes, you may be wondering which medication is right for you – Basaglar vs. Lantus.

Diabetes is a chronic medical condition characterized by high blood sugar levels. It results from either the body’s inability to produce insulin (Type 1 diabetes) or use insulin effectively (Type 2 diabetes).

Left unmanaged, diabetes can lead to serious complications such as heart disease, kidney damage, and nerve damage. Management typically involves a combination of medication, lifestyle adjustments, and regular monitoring of blood sugar levels to ensure optimal health and quality of life.

Basaglar and Lantus are two prominent names of long-acting insulin analogs used to manage diabetes. These medications share a common goal: to help stabilize blood sugar levels in individuals with diabetes by providing a sustained insulin release.

Factors such as their formulation, onset, duration of action, and potential cost considerations can play a role in determining which insulin may be more suitable for an individual’s specific needs. Exploring these differences is vital for healthcare providers and patients to make informed choices in diabetes management.

Mechanism of Action of Basaglar and Lantus

Basaglar is a long-acting insulin glargine medication used to manage diabetes. It mimics the body’s natural insulin production, providing a steady insulin release over an extended period.

Injected subcutaneously, Basaglar helps regulate blood sugar levels by promoting glucose uptake into cells for energy and inhibiting excess glucose production in the liver. This results in more stable and controlled blood sugar levels throughout the day, reducing the risk of hyperglycemia.

Lantus is a type of long-acting insulin glargine used for diabetes management. It works by providing a consistent, slow insulin release into the bloodstream after subcutaneous injection.

This helps regulate blood sugar by facilitating glucose uptake by cells and reducing its production in the liver. Lantus maintains stable insulin levels for up to 24 hours, offering prolonged glycemic control and lowering the risk of high blood sugar.

Lantus and Basaglar are both long-acting insulin glargine options for diabetes control. They share the same mechanism, releasing insulin gradually to stabilize blood sugar levels.
Users might find Basaglar to be more cost-effective. Consulting a healthcare professional for personalized guidance is crucial for optimal diabetes management.



Multiple studies have underscored the efficacy of Basaglar. Clinical trials have demonstrated its effectiveness in lowering and maintaining blood glucose levels in patients with type 1 and type 2 diabetes. Research has indicated that Basaglar’s pharmacokinetic and pharmacodynamic profiles closely align with the reference product, affirming its bioequivalence.

Basaglar is convenient to use due to its once-daily dosing schedule. Furthermore, real-world data studies have shown reductions in HbA1c levels and reduced risk of hypoglycemia. These findings collectively emphasize Basaglar’s role as a reliable option for effective diabetes management, providing patients with a valuable tool to enhance their quality of life.


Lantus has been extensively studied, affirming its effectiveness in diabetes management. Clinical trials have consistently demonstrated its ability to effectively control blood glucose levels in individuals with type 1 and type 2 diabetes.

Its stable and prolonged action provides a steady foundation for glycemic control, reducing the risk of high and low blood sugar fluctuations. Studies have also shown its positive impact on reducing HbA1c levels, a key marker of long-term glucose control.

Patient data analyses further support Lantus’s role in improving overall quality of life and minimizing diabetes-related complications. These findings collectively validate Lantus as a valuable tool in diabetes treatment strategies.

Which medication is more effective?

Basaglar and Lantus exhibit comparable effectiveness in managing diabetes. Clinical trials demonstrate their ability to effectively regulate blood glucose levels in individuals with type 1 and 2 diabetes. Both insulins offer steady glycemic control and reduced risk of hypoglycemia.

Ultimately, the choice between the two should consider factors like patient preference, adherence, and healthcare professional guidance to ensure optimal diabetes management.

Dosage and Administration

Basaglar dosage

Basaglar is commonly dosed once daily at the same time each day, usually in the evening. The exact dosage can vary depending on individual patient needs and medical recommendations.

Basaglar administration

Basaglar is typically administered via subcutaneous injection in the fatty tissue of the abdomen, thigh, or upper arm.

Regular monitoring of blood sugar levels and close consultation with a healthcare provider are essential to determine the appropriate dosage and administration for optimal diabetes management.

Lantus dosage

Lantus is prescribed consistently every day, usually at bedtime, for managing diabetes. The exact dosage varies based on individual patient requirements and medical advice.

Lantus administration

Lantus is administered subcutaneously in the abdominal area, thigh, or upper arm.

Regular blood sugar monitoring and close communication with a healthcare professional are important to establish the right dosage and ensure effective diabetes control.

Comparing dosage and administration

Basaglar and Lantus both offer flexibility with dosing time due to their 24-hour effectiveness, while Lantus.

Adverse Effects

Many patients have questions about Basaglar vs. Lantus adverse effects.

Basaglar adverse effects

Basaglar is generally well-tolerated, but like any medication, it can have adverse reactions. Common adverse reactions include injection site reactions like pain or redness, weight gain, and low blood sugar (hypoglycemia) if the dose isn’t adjusted correctly.

Rarely, allergic reactions can occur. It’s important to monitor blood sugar levels regularly and communicate with a healthcare provider. Severe hypoglycemia or hypersensitivity reactions are rare but possible. Anyone experiencing persistent or severe side effects should seek medical attention. This is not an exhaustive list.

Lantus adverse effects

Lantus is used to manage diabetes but can lead to adverse reactions. Common adverse reactions surround injection site discomfort, weight gain, and hypoglycemia if the dosage isn’t adjusted properly.

Allergic reactions are rare but possible. Some might experience skin reactions, itching, or swelling. In isolated cases, hypokalemia or fluid retention might occur. It’s vital to monitor blood sugar levels consistently and collaborate with a healthcare provider.

Severe hypoglycemia or hypersensitivity reactions are potential but uncommon. If severe reactions manifest, medical attention is imperative.

Comparing Lantus and Basaglar adverse effects

Lantus and Basaglar are both insulin glargine medications for diabetes, and their adverse effects are similar. Basaglar is generally well-tolerated, with common negative effects that include mild injection site reactions and potential weight gain.

Lantus, on the other hand, might lead to similar injection site discomfort and weight gain. Additionally, some people report skin reactions, itching, or swelling with Lantus.

Hypoglycemia is a potential concern for both, especially if dosages aren’t adjusted accurately. While rare, allergic reactions can occur with both medications.


Basaglar interactions

Significant interactions for Basaglar include drugs that affect blood sugar levels: concurrent use with other insulins, oral antidiabetic agents, or certain medications like corticosteroids, beta-blockers, and certain psychiatric drugs that may alter blood sugar control.

Caution is needed when using ACE inhibitors, ARBs, and some antibiotics, as they can impact insulin sensitivity. Careful monitoring is advised when combining Basaglar with these medications to ensure proper glycemic management.

Lantus interactions

Significant interactions for Lantus include medications affecting blood sugar: concomitant use with other insulins, oral antidiabetic drugs, or drugs like corticosteroids and beta-blockers can influence glucose levels.

Caution is also needed with ACE inhibitors, ARBs, and certain antibiotics, as they might impact insulin sensitivity. Careful monitoring is crucial when combining Lantus with these drugs to ensure optimal blood sugar control.

Interaction comparisons

Both Basaglar and Lantus share similar potential interactions due to their mechanism of action. Therefore, neither Basaglar nor Lantus is notably more or fewer interactions-prone than the other.

Both medications can interact with other insulins, oral antidiabetic agents, corticosteroids, beta-blockers, ACE inhibitors, ARBs, and antibiotics, affecting blood sugar control and insulin sensitivity.

Patients using either medication should remain vigilant and consult healthcare providers to manage potential interactions and optimize diabetes treatment. The choice between Basaglar and Lantus should be based on individual patient characteristics and preferences rather than their interaction profiles.

Cost and Availability

The average cost of Basaglar is around $50 to $100 per vial without insurance. However, prices can vary based on location and dosage requirements.

Lantus generally costs between $100 to $200 per vial, though prices can differ based on factors like dosage and location.

Some relief might be found in generic versions of insulin glargine. These alternatives tend to be cheaper, often priced around $50 to $100 per vial. It’s advisable to verify current pricing with local pharmacies due to potential fluctuations.

When comparing affordability and availability, Basaglar and Lantus are similar in cost, ranging from $50 to $200 per vial depending on factors like dosage and location. Generic versions of both are more budget-friendly, with prices around $25 to $100 per vial. Availability may vary by location and pharmacy, so it’s advisable to check locally for the best option.

Basaglar vs. Lantus: Which is Right for You?

Basaglar and Lantus are both used to manage diabetes. They offer similar effects in controlling blood sugar levels, suitable for both type 1 and type 2 diabetes.

Basaglar is a biosimilar to Lantus, meaning it is highly comparable in efficacy and safety. While they share core characteristics, individual responses can vary, making it important for patients and healthcare providers to assess which option best suits the patient’s needs. Consulting a medical professional is crucial for personalized treatment decisions.

Prioritize consulting your healthcare provider before initiating any new medications. Their expertise ensures a tailored approach, considering your medical history, potential interactions, and specific needs. This step fosters informed decisions, promoting both safety and effective treatment outcomes.

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